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Janumet 50/1000 mg Tablets (56 tablets) is a prescription medication for adults with type 2 diabetes mellitus. It contains two active ingredients: sitagliptin (50 mg) and metformin hydrochloride (1000 mg) per tablet.
Sitagliptin phosphate monohydrate equivalent to 50 mg sitagliptin
Metformin hydrochloride 1000 mg
Red, capsule-shaped, film-coated tablet with “577” debossed on one side
Used as an adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes mellitus who are inadequately controlled on their maximal tolerated dose of metformin alone or those already being treated with the combination of sitagliptin and metformin
Can be used in combination with a sulphonylurea, a PPARγ agonist (thiazolidinedione), or insulin if further glycaemic control is needed
The usual dose is one tablet taken twice daily with meals
Tablets should be swallowed whole with water and not split, crushed, or chewed
Dosage should be individualized based on the patient’s current regimen, effectiveness, and tolerability
Maximum recommended daily dose: 100 mg sitagliptin and 2000 mg metformin
Take with meals to reduce gastrointestinal side effects
Renal impairment (eGFR <30 mL/min/1.73 m²)
Acute or chronic metabolic acidosis, including diabetic ketoacidosis
History of a serious hypersensitivity reaction to sitagliptin or Janumet
Risk of lactic acidosis, a rare but serious complication
Assess renal function before starting and periodically during treatment
Not for use in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis
Nausea, vomiting, diarrhea, abdominal pain, loss of appetite
Headache, upper respiratory tract infection
Low blood sugar (especially if used with insulin or sulfonylureas)
